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Video: Rehabilitation Management of the Charcot-Marie-Tooth

Charcot-Marie-Tooth disease - Treatment - NH

  1. The Charcot-Marie-Tooth disease (CMT) causes significant muscular deficits in the affected patients, restricts daily activities (ADL), and involves a severe disability. Although the conservative intervention is the only treatment for the disease, there is no scientific evidence so far on rehabilitation treatment
  2. There's no cure for Charcot-Marie-Tooth disease (CMT), but therapies are available to help reduce your symptoms and enable you to live as independently as possible. As CMT gets worse over time, you'll need to be assessed regularly to check for any changes in your condition
  3. How is Charcot-Marie-Tooth disease treated? There is no cure for CMT, but physical and occupational therapies, braces and other orthopedic devices, and orthopedic surgery can help people cope with the disabling symptoms of the disease. In addition, pain-relief drugs can be prescribed for individuals who have severe nerve pain
  4. Long-term results of reconstruction for treatment of a flexible cavovarus foot in Charcot-Marie-Tooth disease. J Bone Joint Surg Am . 2008 Dec. 90 (12):2631-42. [Medline]
  5. Even though Charcot-Marie-Tooth (CMT) disease is seen frequently, relatively little has been written about the successful treatment of upper limb involvement using tendon transfers. It appears that there are several types of CMT disease and there is extreme variability in the clinical symptoms. The
  6. The main treatment for CMT involves working with an occupational or physical therapist. Optimal management is multidisciplinary, with care provided by neurologists, genetic counselors, nurses, physical and occupational therapists, physiatrists, and orthopedic surgeons

Charcot-Marie-Tooth Disease Fact Sheet National

Charcot-Marie-Tooth disease (CMT) consists of a spectrum of disorders caused by mutations in various genes whose protein products are expressed in myelin and/or axonal structures within peripheral nerves. This topic will review the management and prognosis of CMT. Other aspects of CMT are discussed separately. (See Charcot-Marie-Tooth disease. Treatment for Charcot-Marie-Tooth may include: Physical and occupational therapy to improve function and gait stability Orthotic braces and other devices to support weakened legs Social work consultations to connect you with CMT support group Definition. Charcot-Marie-Tooth, or CMT, is inherited peripheral neuropathy and is found worldwide among all races and ethnic groups. Discovered in 1886 by three physicians, Jean-Martin Charcot, Pierre Marie, and Howard Henry Tooth, CMT affects an estimated 2.6 million people Experimental Treatments for Charcot-Marie-Tooth Disease (CMT) There is no cure for Charcot-Marie-Tooth disease. Nor have scientists come up with any approved therapies to address the underlying causes of the genetic neurological disorder Advise patients with Charcot-Marie-Tooth disease (CMT) about weight management, because obesity makes ambulation more difficult. Encourage exercise within each individual patient's capability. [..

Charcot-Marie-Tooth Disease Treatment & Management

Charcot-Marie-Tooth can't be cured at this time. But treatments such as physical and occupational therapy can often be very helpful. Most people with this condition live to a normal age and remain active Charcot-Marie-Tooth disease is hereditary, so you're at higher risk of developing the disorder if anyone in your immediate family has the disease. Other causes of neuropathies, such as diabetes, may cause symptoms similar to Charcot-Marie-Tooth disease. These other conditions can also cause the symptoms of Charcot-Marie-Tooth disease to become. Charcot-Marie-Tooth disease, or CMT, is named after the three doctors from England and France who first described it over 100 years ago Charcot-Marie-Tooth disease (CMT) is an inherited neurological disorder. It affects the peripheral nerves (nerves outside the brain and spinal cord), causing muscle weakness and numbness. CMT happens because of problems with motor nerves (which control muscles) and sensory nerves (which send sensations to the brain)

Charcot-Marie-Tooth type 4 (CMT4) is a congenital neurologic hereditary disease, part of a group of peripheral neuropathies known as Charcot-Marie-Tooth disease (CMT). According to the mutated gene CMT4 is classified in CMT4A, CMT4B1, CMT4B2, CMT4B3, CMT4C, CMT4D, CMT4E, CMT4F, CMT4G, CMT4H and CMT4J.. Each of these subtypes is very rare and may affect only a particular ethnic group Charcot-Marie-Tooth Treatment. CMT. Your Playlist: 0 . Description. It's a genetic condition that causes problems with the sensory and motor nerves. For some, the progression is so severe that they become wheelchair-bound. Now, there's more on a new treatment that may halt CMT in its tracks Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, affecting approximately 1 in 2,500 people in the United States. The disease is named for the three physicians who first identified it in 1886 - Jean-Martin Charcot and Pierre Marie in Paris, France, and Howard Henry Tooth in Cambridge, England

Treatment of the upper limb in Charcot-Marie-Tooth diseas

Charcot-Marie-Tooth disease progresses slowly over time. Symptoms may worsen, even with proper treatment and the patient's best efforts. Although many people have emotional assistance from family and friends, support groups are available to help people with CMT and their families cope with the progressive nature of the disorder Charcot-Marie-Tooth Disease (CMT) Treatment of inherited neuropathies is conducted by our multidisciplinary team of experts. The neurologist oversees the various needs of the patient and directs care to various subspecialities. Depending on the particular type of neuropathy, the neurologist may provide treatment for neuropathic pain with a. Charcot-Marie-Tooth disease (CMT) is a spectrum of nerve disorders named after the three physicians who first described it in 1886 — Jean-Martin Charcot and Pierre Marie of France and Howard Henry Tooth of the United Kingdom. The term CMT is regarded as being synonymous with hereditary motor sensory neuropathy (HMSN) Charcot-Marie-Tooth (CMT) is an inherited neuromuscular disease that causes nerves to malfunction. This condition affects the peripheral nerves responsible for voluntary muscle movement and also the nerves that convey sensations to the brain. Some of the muscles may become weak. The hands and feet may also lose sensation

Potential treatment path shown for subtype of Charcot-Marie-Tooth disease: A new study could pave the way for developing a viable therapy for CMT patients affected by TyrRS mutations Nov 12, 2019 For the first time, potential treatment path becomes clear for subtype of Charcot-Marie-Tooth disease Nov 6, 201 Hereditary Neuropathy Foundation (HNF) is a non-profit 501(c)3 organization which mission is to increase awareness and accurate diagnosis of Charcot-Marie-Tooth (CMT) and related inherited neuropathies, support patients and families with critical information to improve quality of life, and fund research that will lead to treatments and cures Here is the Press Release: Helixmith Co., Ltd. September 22, 2020 First Patient Receives Engensis Treatment in CMT Phase 1/2a Study September 22, 2020 - Gene therapy developer Helixmith announced today enrollment of the first patient in its Phase 1/2a study involving patients with Charcot-Marie-Tooth (CMT) disease using Helixmith's flagship product Engensis (VM202) 2. Yoga. As muscle rigidity is another issue associated with Charcot Marie Tooth, stretching is an important component of treatment. Yoga is one of the most effective training practices for improving flexibility and balance. Yoga also helps realign the body and correct any issues in muscle development. 3 Patients with Charcot-Marie-Tooth disease should inspect their feet daily to detect breakdown of the skin. In rare situations surgery may be discussed to correct significant deformities around the foot and ankle. Recovery. Charcot-Marie-Tooth disease is a progressive disorder and will require continued treatment throughout a patient's lifetime

CMT1A. Charcot-Marie-Tooth disease (CMT) has a few different subtypes. 60% of all patients diagnosed with type 1 of the rare disease have CMT1A.This subtype means patients have an duplicate copy of PMP22, a gene which works to create the PMP22 protein Although Charcot-Marie-Tooth disease (CMT) is a lifelong condition with no known cure, the symptoms can be managed with appropriate therapies to increase the independence and quality of life of.

Charcot-Marie-Tooth Disease: Causes, Symptoms, Types

Charcot-Marie-Tooth disease is a common inherited neurological condition that can affect your quality of life. But with specialized care from Cedars-Sinai, it doesn't have to slow you down.. Cedars-Sinai is among a handful of nationally recognized Charcot-Marie-Tooth programs in the country. Our renowned specialists deliver advanced treatments that help you get pain relief and prevent. Charcot-Marie-Tooth (CMT) is the most common inherited neurological disorder of the peripheral nerve, affecting approximately 150,000 Americans. It was named after the three doctors — Jean-Martin Charcot, Pierre Marie and Howard Henry Tooth — who first identified the condition in 1886 Charcot-Marie-Tooth Disease, also known as peroneal muscular atrophy, is a common autosomal dominant hereditary motor sensory neuropathy, caused by abnormal peripheral myelin protein, that presents with muscles weakness and sensory changes which can lead to cavovarus feet, scoliosis, and claw foot deformities

Charcot Marie Tooth Disease (CMT), aka peroneal muscular atrophy, causes weakness and loss of sensation in the feet, legs and hands. CMT is the most common inherited neurological disorder and affects approximately 1 in every 2,500 people. Charcot Marie Tooth Disease was first identified in 1886 by three doctors, Jean-Marie Charcot, Pierre Marie. Charcot-Marie-Tooth disease (CMT) is the most commonly used name for a wide variety of inherited neuropathies. More than 70 different genes that cause CMT have been identified, several by Penn clinician-scientists. Learn more about diagnostic testing and treatment options available at Penn Charcot-Marie-Tooth (CMT) disease is a group of disorders in which the motor and/or sensory peripheral nerves are affected, resulting in muscle weakness and atrophy as well as sensory loss. Symptoms occur first in the distal legs and later in the hands. The nerve cells in individuals with this disorder are not able to send electrical signals.

Medical Management - Charcot-Marie-Tooth Disease (CMT

Charcot-Marie-Tooth disease (CMT) is a group of genetic nerve disorders. It is named after the three doctors who first identified it. In the United States, CMT affects about 1 in 3,300 people. CMT affects your peripheral nerves. Peripheral nerves carry movement and sensation signals between the brain and spinal cord and the rest of the body Charcot-Marie-Tooth disease, a genetic nerve condition that primarily affects the feet and hands, may have no cure, but it can be managed with physical therapy and attention to care. Find out more.

Pain Management - Charcot-Marie-Tooth Associatio

Charcot-Marie-Tooth (CMT) disease is a group of genetic disorders that affects movement and feeling in the limbs. The disease progresses slowly and causes damage to the peripheral nerves. These nerves control muscles and transmit sensation. Type I (demyelinating)-This type affects the coating of the nerve called the myelin sheath, causing. Charcot-Marie-Tooth Disease (CMT) is a group of neuromuscular disorders that damage nerves in the legs and arms (also known as the peripheral nerves). CMT disease usually affects the nerves that control movement and sensation. It also affects cells that support and protect nerves *Charcot-Marie-Tooth disease (CMT) facts medically edited on Oct. 28, 2015, by Charles Patrick Davis, MD, PhD. Charcot-Marie-Tooth disease (CMT) is composed of types of inherited neurological disorders that affect motor and sensory peripheral nerves (neuropathy), resulting in weakness in the musculature; the disease may get progressively worse over time nerve function. The most common is Charcot-Marie-Tooth (CMT) disease. These disorders have orthopedic problems and present with weakness, gait abnormalities, sensory loss, and progressive deformities. As with any disease, an understanding of the natural history is important to determine effective treatment. Becaus

Charcot-Marie-Tooth disease (CMT) is known as a hereditary motor and sensory neuropathy (HMSN) and is the most common inherited neuromuscular disease with a prevalence of approximately 1 in every 2,500 [1]. CMT involves the degeneration of nerve fibres in the body that results in muscle weakness and wasting along with a decrease in sensation [2][3] Charcot-Marie-Tooth, the most common rare diseases. Worldwide, 1 in 2,500 people are affected by these inherited neuromuscular diseases. This website is dedicated to the annual awareness campaign organised by the European CMT Federatio Charcot-Marie-Tooth Disease. Make an Appointment. Call 434.924.0000. Schedule Online. Charcot-Marie-Tooth (CMT) disease is a group of inherited disorders caused by a mutation in genes. It affects movement and feeling in your arms and legs. The disease progresses slowly and causes harm to the nerves that control muscles and transmit sensation Charcot-Marie-Tooth disease (CMT) is the umbrella term for a range of inherited genetic conditions affecting the peripheral nervous system (the nerves stretching from the spinal cord to the muscles). Symptoms include progressive weakness and muscle wasting of the legs and arms. The ways people are affected can vary widely Charcot-Marie-Tooth disease encompasses a group of disorders called hereditary sensory and motor neuropathies that damage the peripheral nerves. Peripheral nerves connect the brain and spinal cord to muscles and to sensory cells that detect sensations such as touch, pain, heat, and sound. Damage to the peripheral nerves that worsens over time.

Charcot-Marie-Tooth Disease Johns Hopkins Medicin

Charcot Marie Tooth treatment. There's no cure nor drug treatment for Charcot-Marie-Tooth disease, but physical therapies are available to help reduce your symptoms and enable you to live as independently as possible. As Charcot Marie Tooth gets worse over time, you'll need to be assessed regularly to check for any new developments in your. No clear-cut treatment is available for Charcot Marie Tooth Disease or CMT, but the use of physical therapy, occupational therapy, AFOs, and other assistive devices can be used to diminish the symptoms, which are often disabling.Pain medications are also used for severe pain. Exercises such as muscle strengthening, stretching, endurance training, etc. are useful in increasing endurance of an. This is the case of Charcot-Marie-Tooth Disease (CMT), a disease that is sometimes known as hereditary motor and sensory neuropathy. As the second name would suggest, CMT is a disease that causes neuropathy in both motor and sensory peripheral nerves. The peripheral nerves are nerves that are outside the brain and spinal cord Treatment; The symptoms of Charcot-Marie-Tooth disease (CMT) can differ from person to person, even among relatives with the condition. Symptoms can vary depending on the type of CMT, and even people with the same type can experience it differently WE ARE THE DRIVING FORCE BEHIND CMT RESEARCH FOR A CURE. Our Research. For Patients & Families. STAR: Our Research Strateg

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Possible treatment for Charcot-Marie-Tooth disease discovere

Charcot-Marie-Tooth disease is a hereditary disorder that damages the nerves in your arms and legs. Charcot-Marie-Tooth (CMT) disorder affects the peripheral nerves and is just one of the many types of peripheral neuropathy that can qualify you for disability benefits. Most often peripheral neuropathy is caused by diabetes mellitus Charcot-Marie-Tooth Treatment: CMT Wayne S. Berberian, M.D., chief of Foot and Ankle Service, Department of Orthopaedic Surgery, Hackensack University Medical Center, discusses a condition called Charcot-Marie-Tooth disease (CMT), which is a hereditary motor and sensory neuropathy disease that affects the peripheral nerves in the body

Hand Rehabilitation Treatment for Charcot-Marie-Tooth

There isn't any medication to cure Charcot-Marie-Tooth (CMT). Using anti seizure medications like neurontin helps with the nerve pain. It depends on what a persons symptoms are as to what medication is tried. I also take Effexor XR for the burning neuropathic pain. Pain medications are frequently not useful as they don't help with nerve pain Charcot-Marie-Tooth disease was identified in 1886. Yet for the next 120 or so years there was no organized effort to help find an effective treatment or, better yet, a cure - even though CMT affects one in 2,500 people (about the same prevalence as multiple sclerosis) including 150,000 Americans and nearly 3 million people around the world The Massachusetts General Hospital CMT Center of Excellence provides comprehensive diagnosis, treatment, and education for patients with Charcot-Marie-Tooth disease and other inherited neuropathies Charcot Marie Tooth Disease Treatment 1. Amla Is A Natural Immunomodulator. Since amla is rich in vitamin C as well as antioxidants, it is a potent remedy for CMT disease. Amla helps prevent nerve and muscle damage. Therefore, blend 3 pieces of amla to prepare its juice. Add a few mint leaves, one tablespoon lemon juice, and black salt to taste Charcot-Marie-Tooth disease is one of the most common inherited neuromuscular disorders present in today's society. Those suffering from Charcot-Marie-Tooth disease will have symptoms that include muscle weakness and decreased muscle density that interferes with sensations in the feet and legs — these symptoms can travel to the arms and hands as well

Charcot Marie Tooth Disease Treatment. At present there is no standard treatment for the Charcot-Marie-Tooth disease, but ascorbic acid has been suggested to help cure the disorder. There has been a clinical trial of using ascorbic acid on CMT patients, and high doses of Vitamin C have been used on the said patients, but not all of them are. A potential new treatment approach for hereditary neurological disorder, the incurable Charcot-Marie-Tooth disease, has been found by researchers. Patients with Charcot-Marie-Tooth disease type 1A. Charcot-Marie-Tooth Type 4J (CMT4J) is a rare subtype of Charcot-Marie-Tooth (CMT) that affects the peripheral nervous system — the nerves that lie outside the brain and spinal cord. CMT4J is caused by a genetic variant in the FIG4 gene. Common signs and symptoms in childhood include rapidly progressive muscle weakness and atrophy in the arms. Report. My mother had breast cancer. Although the doctors were told that she had CMT and most chemo drugs were toxic, they still gave her vincristine. She died about 2 weeks after her first treatment. The cancer didn't kill her, the chemo did. Be very cautious when your doctors are treating your cancer

Charcot-Marie-Tooth disease Genetic and Rare Diseases

Charcot-Marie-Tooth disease is a group of disorders that affect the peripheral nerves, the nerves running from outside the brain and spine. Note: There are currently no drugs listed for Charcot-Marie-Tooth Disease Charcot-Marie-Tooth disease is known to cause the peripheral nerves to stop working, causing loss of dexterity and the sense of touch in the hands and feet. Over two decades, Sanders has been. Charcot-Marie Tooth disease is the most common hereditary neurological disease in the world. It affects the peripheral nerves and causes progressive paralysis of the legs and hands. No treatment. Study Description. This is a multicenter, phase 2 study to evaluate the safety, tolerability, pharmacodynamics (PD), efficacy, and pharmacokinetics (PK) of ACE-083 in patients with CMT1 and CMTX, to be conducted in two parts. Part 1 is non-randomized, open-label, dose-escalation and Part 2 is randomized, double-blind, and placebo-controlled

Charcot-Marie-Tooth disease is an inherited neurological disorder that affects your peripheral nerves. Learn about symptoms, causes, and treatment Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, affecting approximately 1 in 2,500 people in the United States. CMT, also known as hereditary motor and sensory neuropathy (HMSN) or peroneal muscular atrophy, comprises a group of disorders caused by mutations in genes that affect the normal function of the peripheral nerves Nov. 21, 2019 — Charcot-Marie-Tooth disease (CMT) is an inherited neurodegenerative condition that affects 1 in 2500 individuals. Currently, however, it is still lacking effective treatment options About Charcot-Marie-Tooth Disease Charcot-Marie-Tooth disease (CMT) is an inherited neurological disease characterized by a slowly progressive degeneration of the muscles in the foot, lower leg, hand, and forearm, and a mild loss of sensation in the limbs, fingers, and toes

Treatment and Therapy. The truth is, there is no cure for Charcot Marie Tooth disease. Several approaches will help alleviate the condition and help individuals cope with normal daily activities. Physical therapy is one of the most common methods that will help prevent muscle wasting and tightening. Different stretching and motion exercises. Charcot-Marie-Tooth disease is the single most common diagnosis associated with cavus foot. The imbalance involving intrinsic and extrinsic muscles has been suggested as the main pathogenetic cause of cavus foot in this disease. The goal of surgical treatment is to correct the deformity to obtain a plantigrade foot According to a story from Charcot-Marie-Tooth News, a recent study has demonstrated the potential impacts of an RNA-based therapy as a treatment for type 1A Charcot-Marie-Tooth disease. The treatment was able to normalize motor function and muscle strength in two different mouse models of the disease, including a model meant to represent severe disease Charcot-Marie-Tooth Disease (CMT) or hereditary motor sensory neuropathy (HMSN) is an inherited, progressive disease of the nerves with weakness and numbness more pronounced in the legs than the arms. The nerves stop sending messages to different areas of the body, like the hands and feet, because parts of the nerve cells deteriorate

Charcot-Marie-Tooth disease is a broad spectrum of different types of inherited peripheral neuropathy. The most common types affect motor and sensory nerves and cause muscle wasting and sensory loss. There have been few trials of treatment for Charcot-Marie Tooth disease This is a fictional case presentation based on a university aged varsity male soccer player who incurred a recent diagnosis of Charcot-Marie-Tooth Disease (CMT). The case study documents from the initial physiotherapy assessment and diagnosis through to follow up treatments throughout the patient's lifespan. It highlights the primary challenges experienced by the patient, the patient.

Charcot-Marie-Tooth disease: Management and prognosis

Charcot-Marie-Tooth (CMT) disease, also known as hereditary motor and sensory neuropathy (HMSN), encompasses the majority of hereditary peripheral neuropathies. Both motor and sensory nerves are typically affected, with symmetrical changes noted on nerve conduction studies The gene encoding ganglioside-induced differentiation-associated protein 1 is mutated in axonal Charcot-Marie-Tooth type 4A disease. Nat Genet 2002; 30:22. Pedrola L, Espert A, Wu X, et al. GDAP1, the protein causing Charcot-Marie-Tooth disease type 4A, is expressed in neurons and is associated with mitochondria MFN2 hereditary motor and sensory neuropathy (MFN2-HMSN) is a classic axonal peripheral sensorimotor neuropathy, inherited in either an autosomal dominant (AD) manner (~90%) or an autosomal recessive (AR) manner (~10%). MFN2-HMSN is characterized by more severe involvement of the lower extremities than the upper extremities, distal upper-extremity involvement as the neuropathy progresses, more.

Charcot-Marie-Tooth Disease Natural Ayurvedic Treatment. Charcot Marie Tooth disease or CMT is a common neurological disorder affecting the nerves and muscles. It is a hereditary disorder that causes sensory and motor neuropathies. Hence, it is also called a hereditary motor-sensory Neuropathy. This condition affects the peroneal muscles. Treatment: Official Title: Phase I/IIa Trial Evaluating scAAV1.tMCK.NTF3 for Treatment of Charcot-Marie-Tooth Neuropathy Type 1A (CMT1A) Estimated Study Start Date : August 2021: Estimated Primary Completion Date : March 1, 2023: Estimated Study Completion Date : July 1, 202

This video featuring people affected by Charcot-Marie-Tooth disease (CMT) and specialist neuromuscular health professionals is an introduction to the main fa.. Treatment and prognosis. Unfortunately no effective drug for Charcot-Marie-Tooth disease exists. Treatment is largely supportive with rehabilitation therapy and surgery for skeletal deformities 5. Most patients with CMT1A (the most common form of Charcot-Marie-Tooth disease) will remain able to walk for their entire life Charcot-Marie-Tooth disease (CMT) is the most commonly in-herited neurological disease, with an incidence equal to that of mul-tiple sclerosis (1 in 2,500 people). There are currently 2.8 million people with CMT—so why don't podiatrists treat more people with this disease? With over 70 genetic variations of CMT now identified Charcot-Marie-Tooth disease type 1 A (CMT1A) lacks an effective treatment. We provide a therapy for CMT1A, based on siRNA conjugated to squalene nanoparticles (siRNA PMP22-SQ NPs). Their.

Charcot-Marie-Tooth disease

*Charcot-Marie-Tooth disease (CMT) facts Readers Comments 2 Share Your Story *Charcot-Marie-Tooth disease (CMT) facts medically edited on Oct. 28, 2015, by Charles Patrick Davis, MD, PhD Charcot-Marie-Tooth disease (CMT) is composed of types of inherited neurological disorders that affect motor and sensory peripheral nerves (neuropathy), resulting in weakness in the musculature; the disease. Scientists zero in on treatment for Charcot-Marie-Tooth disease. Mar 08, 2018 'Yin and yang' enzymes evolved over billions of years to protect against cancer. Aug 21, 2019 Charcot-Marie-Tooth is one of the most common nerve-related disorders passed down through families (inherited). Changes to at least 40 genes cause different forms of this disease. The disease leads to damage or destruction to the covering (myelin sheath) around nerve fibers

Charcot-Marie-Tooth Treatment Stanford Health Car

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Pain - Charcot-Marie-Tooth Associatio

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Charcot-Marie-Tooth disease type 4 Genetic and Rare

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Charcot-Marie-Tooth Disease (CMT) - Diseases Muscular

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